邢唷> mol欹'` 餜,;bjbj8frr3 28T"T28N  ?8A8A8A8A8A8A8$;hv=^e8A$A$A$e84z8***A$*?8*A$?8**n5s7v 屢犔k(6 7D8086=)D>@s7s7`=L >$7(!*!x"e8e8)^8A$A$A$A$222d222222  Zhejiang University-University of Alberta First Biomedical Symposium Hangzhou, China November 19, 2011 Supported by: Zhejiang University, School of Medicine University of Alberta, Faculty of Medicine and Dentistry Saturday November 19, 2011 locations: Zhejiang University School of Medicine (administration building 701) Opening Session Who we are and why are we here 9:00 9:10 Introduction and welcoming remarks Drs. Hu Hu (Zhejiang University) and Luis Schang (University of Alberta) 9:10 9:30 Distinguished Speakers Dr. Zhenpin Xu Professor and Vice-Dean Research Dept. of Biochemistry Zhejiang University Hangzhou, China Dr. Marek Michalak Professor and Vice-Dean Research Dept. of Biochemistry University of Alberta Edmonton, Alberta, Canada First Oral Session Neuromodulation 朒ow the brain works 9:30 - 9:50 揘euregulin, Interneurons and Epilepsy Dr. Xiaomin Li, Professor, Dept. of Neuroscience, Zhejiang University 9:50 - 10:10 揂dventures in NPY Dr. W Colmers, Professor and AHFMR Medical Scientist, Department of Pharmacology, and Lead, School of Neuroscience, Faculty of Medicine and Dentistry, University of Alberta, Edmonton Alberta Canada 10:010-10:20 Questions and discussions 10:20-10:30 Break Second Oral Session Autophagosomes in health and disease 10:30 - 10:50 揜egulation of autophagosome-lysosome fusion Dr. Gary Eitzen, Associate Professor, Department of Cell Biology, University of Alberta, Edmonton Alberta Canada 10:50 - 11:10 揜egulation of Autophagosome Formation in Mammalian Cells Dr. Wei Liu, Professor, Dept. of Biochemistry, Zhejiang University 11:10-11:20 Questions and discussions 11:20-11:30 Break Third Oral Session - Diabetes 11:30 - 11:50 揟he application of MRI-based molecular imaging in the fields of islet transplantation and diabetes. Dr. Yulian Wu, Professor, the second affiliated hospital, Zhejiang University 11:50 - 12:10 揘eonatal Porcine Islet Transplantation for the Treatment of Type 1 Diabetes Dr. Gina Rayat, Associate Professor and Associate Director of Graduate Education, Department of Surgery; Director, Pancreatic Isolation and Transplantation Core Lab, Alberta Diabetes Institute. University of Alberta, Edmonton Alberta Canada 12:10-12:20 Questions and discussions 12:30 13:30 LUNCH Fourth Oral Session Viral disease 13:30 - 13:50 揊unctional characterization of Immune-related genes Dr. Lingron Lu, Professor, Dept. of Immunology, Zhejiang University 13:50 - 14:10 揑nnovative approaches to antiviral therapies Dr. Luis Schang, Associate Professor; Department of Biochemistry and Department of Medical Microbiology and Immunology, Li Ka Shing Institute of Virology, University of Alberta, Edmonton Alberta Canada. 14:10-14:20 Questions and discussions 14:20-14:30 Break Fifth Oral Session- Cardiovascular disease 14:30 - 14:50 揑nsights into the expression, mutual regulation and function of metalloproteinases in the cardiovascular system Dr. Carlos Fernandez-Patron, Department of Biochemistry, School of Translational Medicine, Cardiovascular Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton Alberta Canada 14:50 - 15:10 揚latelet, thrombosis and beyond Dr. Hu Hu, Professor, Dept. of Pathology and Pathophysiology, Zhejiang University 15:10-15:20 Questions and discussions 15:20-15:30 Break 16:30-17:00 Round Table discussion: 揌ow do we move forward to sustain the collaborations between our Universities? (moderators, Drs. Hu Hu and Schang) 17:00-17:30 Final conclusions and closing comments Drs. Xu and Michalak 18:00 22:00 DINNER Speakers Biographies Dr. Xiao-Ming Li Dr. Xiao-Ming Li is a professor of Neurobiology. He earned the M.D. in 1996 and Ph.D. in 2003 from First Military Medical University. He worked as a Resident Physician, Attending Physician in a Military Hospital during 1996-2004. He got his postdoctoral training at Dept. of Neurology, Medical College of Georgia, USA during 2005-2007. After that, he worded as an Assistant Research Scientist at Institute of Molecular Medicine and Genetics of this college from 2007-2008. In August, 2008, he joined Zhejiang University. His main research interests is to understand the molecular mechanisms underlying the formation, maintenance and regulation of neuronal circuit and synaptic functions, in identifying targets to develop therapeutic strategies for treating neurological disorders including ischemic injury, schizophrenia, and epilepsy. Dr. William Colmers Dr. Bill Colmers was appointed Assistant Professor in Pharmacology at the University of Alberta in 1988, Associate Professor in 1992 and Professor in 1999. Prior to that, he did his doctorate in natural sciences (Dr. rer. nat.) in Regensburg, Germany, and did postdoctoral fellowships at Duke University, the University of Texas Health Sciences Center in San Antonio, the University of Calgary and the Vollum Institiute in Portland, Oregon. His research has focused on the actions and biological role of neuropeptides, particularly Neuropeptide Y (NPY), in several regions of the central nervous system. On going work relates to the role of NPY and its different receptors in the hypothalamic regulation of appetite and energy balance, and the regulation of anxiety and stress in the basolateral amygdala. Dr. Gary Eitzen Dr. Gary Eitzen was appointed as a Professor of Cell Biology at the University of Alberta in 2002. Dr. Eitzen earned his Ph.D. from The University of Alberta in 1997, under the mentorship of Dr. Richard Rachubinski. This work led to the discovery of genes needed for peroxisome biogenesis. His postdoctoral research was performed in the Department of Biochemistry at Dartmouth Medical School in the lab of Dr. William Wickner. This work led to the discovery of a role for Rho GTPases and dynamic actin remodelling in vesicle docking and membrane fusion. Studies in Dr. Eitzen抯 lab are aiming at understand the role of Rho GTPases in vesicular transport and membrane fusion. Ongoing projects include: lysosome biogenesis and fusion, regulation of immune cell exocytosis and targeted inhibition of Rho signalling. Dr. Wei Liu Dr. Wei Liu was appointed a Professor of Cell Biology at Zhejiang University School of Medicine in 2007. Dr. Liu earned his M.D. from the Fourth Military Medical University in 1987, and received his Ph.D. from Nagoya University (Japan) in 1998. His postdoctoral research in Department of Immunology at Nagoya University was immediately followed by an appointment as Assistant Professor at Aichi Medical University (Japan) in 1999. He then worked in Jennifer Lippincott- Schwartz抯 lab at NIH (USA) as a visiting fellow and research fellow from 2001-2007. Studies in Dr. Liu抯 group are aiming to understand the molecular mechanisms underlying endomembrane structure and function. Their ongoing projects include: biogenesis of autophagosomes in mammalian cells, dynamics of autophagy-related proteins, and regulation of mitotic Golgi disassembly. Dr. Hu Hu Dr. Hu Hu graduated from Zhejiang University School of medicine in 1996 and received his Ph. D. from the Karolinska Institute in Sweden in 2003. He then worked as a postdoctoral at Center for Molecular and Vascular Biology (CMVB), University of Leuven, Belgium during 2004-2005. He returned to Zhejiang University School of Medicine and worked as an associate professor since 2006, promoted as Professor in Pathology in 2010. His major research interests are the molecular mechanisms involved in platelet activation and thrombosis. His team is also interested in elucidating the mechanisms underlying platelet-leukocyte/cancer cell interaction, which are of importance in facilitating the pathophysiological situations such as inflammation and tumor metastasis. Dr. Carlos Fernandez-Patron Dr. Carlos Fernandez-Patron was originally born in Cuba. During his undergraduate and Master studies he爐rained in physics, specializing in solid state physics at low temperatures at the University of Technology in Dresden, Germany. In addition to his studies in experimental physics, he took additional courses on theoretical physics with a focus on quantum mechanics. Dr. Fernandez-Patron's PhD thesis was in the area of 'proteomics' at the Center for genetic Engineering and Biotechnology, in Havana, Cuba. His work is best known for爃is invention of a new method for protein detection using heavy metal ions. This method爃as been爉arketed worldwide by numerous companies since 1995. During his PhD and post-doctoral studies, Dr. Fernandez-Patron also has trained at The Wellcome Research Labs in Beckenham, UK, and the Zentrum fuer Molekulare Biologie and the European Molecular Biology Laboratory, both in Heidelberg, Germany. In 1997, Dr. Fernandez-Patron started a post-doctoral fellowship at the University of Alberta, Canada; where, in 2001, he continued his career as an independent investigator in the department of Biochemistry. Dr. Fernandez-Patron's laboratory investigates hypertensive cardiac disease with a focus on the biology of metalloproteinases. Dr. Linrong Lu Dr. Linrong Lu has been trained in both molecular biology (Shanghai Institute of Biochemistry) and immunology (Harvard Medical School). His primary research interest is to elucidate the molecular pathways and cellular interactions that mediate and regulate immune response including both innate and T cell mediated immune response by using molecular biology and genetic approaches. We are especially interested in the identification and characterization of novel immune-related genes and the development and treatment of autoimmune diseases. Main approaches used in the lab include molecular biology approaches, gene knock-out, cell culture, mouse model of autoimmune diseases Dr. Luis Schang Dr. Luis Schang is an Associate Professor at the Departments of Biochemistry and Medical Microbiology and Immunology at the University of Alberta, and a member of the Li Ka Shing Institute of Virology. He earned his DVM degree at the Universidad de Buenos Aires (Argentina), his Ph.D. in molecular virology at the University of Nebraska-Medical Center (USA) and his postodoctoral training, also in molecular virology, at the University of Pennsylvania. He has published 38 original research papers, 3 book chapters and 4 non peer-reviewed publications. He is the inventor in 5 ongoing patent applications, one of which is currently undergoing commercialization negotiations. He holds research funding from the CIHR, PrioNet, and the Burroughs-Wellcome Fund. The personnel in his group are also funded by the CIHR, NSERC, and several grants from the Province of Alberta or the University of Alberta. Dr. Schang is particularly interested on the roles that cellular proteins and lipids play in infection, replication and pathogenesis of infectious agents, viruses and prions, with the ultimate goal of finding novel antiviral drugs with unique mechanisms of action. As a model for his studies, he uses viruses such as herpes simplex, cytomegalovirus, influenza or hepatitis C virus, and prions such as scrapie. Dr. Gina Rayat Dr. Gina R. Rayat is Associate Professor and Associate Director of Graduate Education in the Department of Surgery at the University of Alberta. She received her Bachelor of Science degree major in Molecular Biology at the University of Winnipeg in 1988 and completed her Master of Science degree in Transplantation Immunology at the University of Manitoba in 1992. She completed her Ph.D. training at the University of Alberta in 1999 and moved to Denver, Colorado, USA for a postdoctoral training at the Barbara Davis Center for Childhood Diabetes in the University of Colorado Health Sciences Center. In 2003, she returned to Edmonton and was appointed Assistant Professor in the Department of Surgery at the University of Alberta. Her focus of research is to understand the mechanism(s) of islet xenograft rejection and to develop safer strategies for preventing rejection and induction of tolerance to islet xenografts. Dr. Yulian Wu Dr. Yulian Wu is the director of Department of Hepatic-biliary-pancreatic Surgery in 2nd affiliated hospital of Zhejiang University. She received her Bachelor of Medicine in 1983, and completed her Master of Medicine major in Hepatic-biliary-pancreatic Surgery in 1989. During 1994-1995, she went to Institute of Surgical Research at Universit鋞 zu L黚eck in Germany for further study. She completed her Ph.D. training major in Hepatic-biliary-pancreatic Surgery in 1998. In 2000, 2003 and 2004, she went to Montreal University as visiting scholar participating in islet transplantation research projects funded by the Juvenile Diabetes Foundation (JDF) and Canadian Institute of Health Research (CIHR). Her focuses of research are: 1) to understand the relationship between pancreatic cancer and diabetes; 2) molecular imaging of islet grafts; 3) strategies for overcoming the chemotherapy resistance of pancreatic cancer.       $,-3>HNO_ijpq 0 M O 镡镡镡镌镡枚枚枚毛湯湉垊}vhVhVh#h塝#h,5丆JOJQJnHtHh塝#h,5丆JOJQJ h猅h, hdyh,h, h塝#h,h塝#h,CJOJQJh塝#h,OJQJnHtHh塝#h,OJQJh塝#h,CJ0OJQJ h塝#h,CJ0OJQJnHtHh,CJ4OJQJnHtHh塝#h,CJ4OJQJ h塝#h,CJ4OJQJnHtHHIJKLMNO_q O P @ €€gd,gd,gd,dh$刾勑dh^刾`勑a$gd, $dha$gd,$dha$dhgd,;+;P Q R      N O _ € $ €a$gd,$a$gd,gd,gd,$a$gd, $ p€a$gd, p€gd, @ €€ @ €€gd,O Q R a d     6 N O S ] _ m 庠殴須須韻|峾n|須須`S須韻h塝#h,CJ OJQJh塝#h,>*CJ OJQJh,CJOJQJnHtH h塝#h,CJOJQJnHtHh塝#h,CJOJQJh塝#h,OJQJnHtHh塝#h,56丆J OJQJh塝#h,5丱JQJh,5丆J OJQJ^JaJh塝#h,5丆J OJQJh,5丆J OJQJh塝#h,OJQJh,OJQJm  €  5 6 9 : O ^ ` a s t u 镛艳亚押溠迶墈i^M{=h塝#h,56丆J OJQJ h`#5丆J OJQJnHo(tHh`#5丆J OJQJ#h塝#h,5丆J OJQJ^JaJh塝#h,5丆J OJQJh塝#h,OJQJh,OJQJh塝#h,5丱JQJ#h塝#h,5丆J OJQJnHtHh塝#h,CJ OJQJh#CJOJQJh塝#h,CJOJQJ h塝#h,CJOJQJnHtHh塝#h,5丱JQJmH sH    6 7 8 9 : u v  劆&鸮劆`&鹓d, \ €€劧騘`劧騡d,劆刞1$7$8$H$^劆`刞鷊d, @ €€ @ €€gd, J €€gd,$a$gd,$ €a$gd,  #    T d LMRY[疋制制糕肘牳猸癍槶姯犫譅糕w制制糕kh塝#h,5丱JQJ$h塝#h,OJQJ^JaJnHtHh塝#h,5丆J OJQJh,OJQJh塝#h,OJQJaJ h塝#h,OJQJh塝#h,56丱JQJh塝#h,6丱JQJnHtHh塝#h,6丱JQJh塝#h,OJQJ^JaJh塝#h,OJQJnHtH*      T U M \ €€劧騘`劧騡d, 匉勌鷁匉`勌鷊d,劆刞1$7$8$H$^劆`刞鷊d, \ €€gd, \ €€gd, @ \ €€€gd,$ @ \ €€€€a$gd, \ €€凧 劧騘凧 `劧騡d,e,-z$ @ \ €€€€a$gd,gd, & F 劆刞鷁劆`刞鷊d, \ €€劧騘`劧騡d,劆刞1$7$8$H$^劆`刞鷊d, @ \ €€€€gd, @ \ €€€€劆刞鷁劆`刞鷊d, $ @ \ €€€€a$ @ \ €€€gd, ceu$-./EFGk矜祖兹集爯鎮孺祖t燃tg鎊R馢骜h,OJQJh塝#h,5丱JQJh,5丱JQJh塝#h,OJQJaJ h塝#h,OJQJ]乛Jh塝#h,56丱JQJh塝#h,6丱JQJnHtHh#6丱JQJnHo(tHh#6丱JQJnHtHh塝#h,6丱JQJh塝#h,OJQJ^JaJh塝#h,OJQJnHtHh塝#h,OJQJh塝#h,5丆J OJQJ-./DEFGkl4 \ €€凧 劧騘凧 `劧騡d, 劆勧鮚劆`勧鮣d, \ €€劧騘`劧騡d,劆刞1$7$8$H$^劆`刞鷊d, \ €€gd, \ €€gd, \ €€刞鷃刞鷊d, 8\ €€劆刞鷁劆`刞鷊d,k{24-.:=>Rhijz 蹑踝跛蛔踝水俗蹑酡搮s卌鮑姿Uh塝#h,OJQJ\乤Jh塝#h,56丆J OJQJ"h塝#h,5丆J OJQJ\乤Jh塝#h,5丆J OJQJh塝#h,OJQJ^JaJh,OJQJ^JaJh塝#h,OJQJaJ h塝#h,6丱JQJnHtHh塝#h,6丱JQJh塝#h,OJQJ^JaJh塝#h,OJQJnHtHh塝#h,OJQJ'(:;<=>jk>de \ €€劧騘`劧騡d,劆刞1$7$8$H$^劆`刞鷊d, @ €€gd, @ \ €€€€劆刞鷁劆`刞鷊d, \ €€凧 劧騘凧 `劧騡d, @ \ €€€gd,$ @ \ €€€€a$gd,<=>jkwxy{|!HOR^_a蜚厣厣憬阖韶洂倹倹倹rerer悅泜泜r倫俽h,56丆J OJQJh塝#h,56丆J OJQJh塝#h,5丆J OJQJh,5丆J OJQJ#h塝#h,5丆J OJQJnHtHh塝#h,6丱JQJnHtHh塝#h,6丱JQJh塝#h,OJQJnHtHh塝#h,OJQJh塝#h,OJQJ^JaJh塝#h,56丱JQJ'ewxyzH_`abyYD2gd, @ \ €€$ @ \ €€a$gd, @ \ €€劆刞鷁劆`刞鷊d, @ \ €€劆刞鷁劆`刞 @ \ €€gd, @ \ €€€gd,acdyz`pqw]m4<%&7h i j v 襁裥咝吡瀺侎吡tbSh塝#h,CJ OJQJaJ "h塝#h,5丆J OJQJ\乤J h塝#h,OJQJaJ h,OJQJ^JaJ!h#OJQJ^JaJnHo(tHh#OJQJ^JaJnHtH$h塝#h,OJQJ^JaJnHtHh塝#h,OJQJ^JaJh,5丆J OJQJnHtH#h塝#h,5丆J OJQJnHtHh塝#h,5丆J OJQJ&'7h j v ####&&&+++..3333r7gd, 1$7$8$H$gd, @ \ €€gd,YD2gd,v z ""#####3&R&&&&&&++++...镡镡镆喇怙猡猱巰n]G€n+h塝#h,5丆J OJQJmHnHsHtH h塝#h,CJ OJQJnHtH#h塝#h,OJQJ\乤JnHtHh塝#h,OJQJ\乤J+h塝#h,5丆J OJQJmHnHsHtHh#OJQJ^J#h#h,5丆J OJQJnHtH#h塝#h,5丆J OJQJnHtHh塝#h,5丱JQJnHtHh塝#h,OJQJ^J h塝#h,OJQJ^JnHtH.333f4.676s777788;;;!;";$;%;';(;+;,;疋新仿伐枂杫h衊\`\`\`\h/jh/U h塝#h,0JOJQJnHtHh塝#h,0JOJQJh塝#h,H*OJQJnHtHh塝#h,OJQJnHtH#h#h,5丆J OJQJnHtHh塝#h,OJQJh塝#h,OJQJ]乛J#h塝#h,5丆J OJQJnHtHh塝#h,OJQJ^JaJh塝#h,OJQJ^JaJr7s77;; ;!;#;$;&;';);*;+;,; @ \ €€gd,gd,6€1恏:p,靶/ 班=!"褒#愋$愋%靶靶 愋t惡髜l楘€葌h~t惡髜l楘€葌h~t惡髜l楘€葌h~04@4 ck噀CJ_HmH sH tH .@. h槝 1$@&5D@D h槝 2$$@&a$5丆J(OJPJQJ2@2 h槝 3$@&5丆J.@. h槝 4$@&>*8@8 h槝 5$$@&a$5丆J N@N h槝 6$ p€€刾@&^刾 B*CJph$A@$ 貫祂=刉[SOFiF 0nf恏@* h槝$a$5&J@& oRh槝5>C@> ck噀噀,g)蹚勽  dh^勽 ` :R@": ck噀噀,g)蹚 2凘 dh^凘 :S@2: ck噀噀,g)蹚 3劺dh`劺6B@B6 ck噀噀,g$ @ €€a$.R. 碙yb鑜Fh噀,gCJaJ,L@, u錯g刣VD ^刣V@rV 羪u w'$ 9r &dG$Pa$CJaJmHsH:﨩: 羪 Char Char1 CJaJtH > @> 羪u 9r G$CJaJmHsH8﨩8 羪 Char Char CJaJtH &﨩& 閝-ppx_en48﨩8 cKapple-style-spanN^@N AGM0nf(Q賨)[$\$OJQJ^JaJnHtH,3fHIJKLMNO_qOPQRNO_€6789:uvTUMe  , - . / D E F G k l 4  ' ( : ; < = > j k > d e w x y z H_`aby&'7hjv###&&++++r/s//33 3!3#3$3&3'3)3*3-30€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€H0€€0€€0€€0€€0€€(0€€(0€€(0€€(0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€ 0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€€€€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€€€H妊00葢00妊00葢00妊00葢00妊00葢00葢00P O m kav .,;"#%(*,.01P -er7,;!$&')+-/2+; 餈  @€€€餒 0(  饞0(  養 S  ? 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