MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01D1F48C.E5DC16A0" ���ĵ�Ϊ�������ļ���ҳ����Ҳ��Ϊ��Web �������ļ������������Ϣ����������������༭����֧�֡�Web �������ļ���������֧�֡�Web ����������������� Windows? Internet Explorer?�� ------=_NextPart_01D1F48C.E5DC16A0 Content-locations: file:///C:/7DF22908/20.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" 浙江大学高校教师= 987;业技术高级职务

 

 

 

 

浙江大学高校教师= 987;业技术高级职务

申报表

 

 

 

   = 号:

0013084

   = 名:

陈烨

   = 位:

医学院

所在学科:

细胞生物学

现任专业技术职务ᦂ= 6;

申请专业技术职务ᦂ= 6;

教授

联系电话:

18457179899

E= -mail:

yechency@zju.guoxinschool.com

 

 

 

 

3Dewm

填报日期:2019年09月24日

 


 

&= #12289;简况

姓名=

陈烨=

性别=

出生年月

1983-10-03=

国籍=

中国=

现党政职务

现工作单位

医学院

现专业<= span style=3D'font-family:SimSun;mso-bidi-font-weight:bold'>技术&#= 32844;务

资格/任职时= 间

/

现聘&#= 20219;专业技术职务/聘任时间

/

所在二级学科

细胞生物学

申请专业

技术职务

教授=

从事&#= 19987;业及专长

长期从事耳聋等重要疾病致病机制及临床转化应用研究,在遗传资源保存利用、实验动物疾病模型建立、及细胞与机体微环境相互调控等方面有较好的工作积累。<= span lang=3DEN-US style=3D'font-family:SimSun;mso-hansi-font-family:Times;mso-= bidi-font-weight: bold'>

最后&#= 23398;历/时间、毕业学= 657;、所学专业、导师姓= ;名

博士研究生毕业/2009-06 、浙江大学、细胞生物学、邵建忠=

最高学位/时间、授学位单位、获= 3398;位专业、导师姓名=

博士/2009-06、浙江大学、、邵建忠

联系&#= 30005;话及Email

18457179899  yechency@zju.guoxinschool.com

主要学术兼= ;职

浙江省遗传学会 第九届理事会 常务理事

<= /o:p>

 

个人简历(要求从&= #22823;学开始,采用时间= 498;序方式填写,所有时= ;间不间断)

学习及进修= ;经历

学习经= 1382;:

自何年= 6376;至何年月,何学校ᦀ= 8;何单位),何专业,&= #23398;历,学位,导师

1) 2004-09至2009-06, 浙江大学, 细胞生物学, 博士研究生毕业, 博士,
2) 2000-09至2004-06, 浙江大学, 生物科学, 全日制普通高校本科毕业, 学士,

 

= 进修经历:

= 自何年月至何年月,= 0309;学校(何单位),๢= 7;修内容,合作导师

 

工作经历

校外工= 0316;简历:

自何年= 6376;至何年月,在何地ᦁ= 2;何学校(何单位),&= #20219;何职(海外职位英= 991;表述),曾任技术职= ;务

1) 2009-09-01至2013-06-30, US, MD Anderson Cancer Center, research fellow,
<= o:p>

 

校内工= 0316;经历:

自何年= 6376;至何年月,单位,ߎ= 7;业技术职务

1) 2015-03至, 医学院,
2) 2013-07至2015-03, 生命科学学院-遗传学与再生生物学研究所,
=

 


二、主要学术成就<= /span>

2.1 <= /span>标志性成果(不&#= 36229;过300字)

1)  确定了212 SNP位点的耳聋基因突变热点组合,中国人群筛查覆盖率可达69.01%,远高于现行产品的30%,制备的Panel已获浙江省卫计委、物价局批准;

2)  分析了1167个汉族非综合征性耳聋患者GJB2基因突变频谱,发现不同于欧洲人群的异质性;

3)  提出了线粒体单体型B是亚洲携带12S rRNA 1555A> G突变人群出现听力损失的一个风险因素;

4)  在国际上首次利用斑马鱼在整体水平开展线粒体tRNA与听觉异常研究,与管敏鑫教授团队合作阐明了耳聋元凶”Mtu1的致病机制,研究成果发表于知名学术期刊 Nucleic Acids Res》;论文发表后,《人民日报》(20180914 12 版)、《新华网》等主流新闻媒体就该工作进行了采访报导,《科学网》等多家网络媒体对上述特别报道进行了转载。


2.2主要学术成 = 489;、贡献、创新点科学= ;价值或社会经济意义&#= 21450;影响力(不&#= 36229;过3000字)

专业背景与研究方向:申请人于20009月至20046月在浙江大学生命科学学院生物科学专业学习,获学士学位并保送细胞生物学专业攻读博士学位,师从邵建忠教授,主要从事疾病动物模型及干细胞体外分化诱导体系建立的相关研究,于20096月获博士学位;同年9月赴美国MD Anderson Cancer Center深造,在著名医学专家Michael Andreeff教授指导下从事临床相关研究(Clinical research),致力于利用成体干细胞在动物模型中构建人源化微环境及临床细胞样本库的建立;20137月以海外高层次人才引进方式加入浙江大学遗传学研究所,申请人积极响应政策号召、全情投入推进残疾预防,建设健康中国的事业,依托本单位在遗传学研究及家系资源收集等方面的优势,结合自身在动物模型构建及原代细胞培养的工作特长,将研究方向定位在“耳聋的致病机制及防治研究”。申请人具有系统全面的遗传学、细胞生物学专业背景和多年扎实的研究基础,研究经历与取得的成果兼具系统性和递进性,研究方向思路清晰,目前主要从事的耳聋研究方向虽然小众,但防聋治聋是我国构建和谐社会、提高人口素质所面临的重大医学和社会问题,也是社会经济长远发展的重大需求。

主要学术成绩小结:申请人长期从事人类重要疾病致病机制及临床转化应用的相关研究,在遗传资源保存利用、实验动物疾病模型建立、及细胞与机体微环境相互调控等方面有较好的工作积累,取得了一定的学术成绩:截至20199月,以第一作者或共同作者在JCI等国际权威学术期刊发表SCI论文33篇(第一作者/通讯作者/共同通讯作者21篇),影响因子累积超过170分,他引1300余次;其中,20137月入职浙江大学以来申请人署名发表的SCI论文共23篇(通讯作者/共同通讯作者12篇);过去5年中,申请人带领研究团队主要围绕遗传性耳聋致病机制开展工作,在耳聋研究方向上获得了2项国家自然科学基金面上项目资助,并作为主要学术骨干参与单基因聋病发病机制研究973计划项目和关于干细胞治疗感音性听力损失新技术研究的浙江省重点研发计划,相关工作也获得了国内外听觉研究同行的积极评价,20152017年分别为Protein Cell和中华耳科学杂志英文版(Journal of Otology)撰写主题为遗传性耳聋新机制线粒体功能异常与药物性耳聋的综述文章。

5年来主要工作的创新点及其科学价值或社会经济意义

耳聋是重大的医学和社会问题,根据残联的统计数据,我国约有3000万重度耳聋患者,是仅次于肢体残疾的第二大残疾群体,其中遗传性耳聋患者高达1600万,每700-1000个新生儿中就有一位聋儿;“防聋治聋”是我国社会经济长远发展的战略性需求。近5年来,申请人充分发挥在实验动物疾病模型建立、遗传资源保存利用等方面的特长,带领团队开展遗传性耳聋机制研究,目前已经取得了较好的数据积累并获得了若干创新成果:  

(1)    耳聋遗传资源库的建立及高覆盖率的耳聋基因突变位点热点组合筛选:我国遗传性耳聋多发、且具有复杂的遗传异质性,大部分致聋基因的频谱有待进一步阐明。在973计划项目单基因遗传性聋病的分子机制研究框架下,团队与浙江大学、杭州师范大学、山东大学、中南大学、兰州大学和解放军301医院等单位的多个研究组协作,以浙江、山东、湖南、甘肃、北京地区为基础建立了全国范围的遗传性耳聋遗传资源库;本课题组累计收集符合标准的耳聋病例样本2577例及健康对照样本500余例,并对样本的发病年龄、家系信息、听力损害程度、常见致聋突变等进行了系统分析,综合分析后获得212“16+2+194”SNP位点的热点突变组合体系,在中国人群中的筛查覆盖率可达到69.01%,远高于市面现行筛查试剂盒30%左右的覆盖率。制备的耳聋基因检测Panel已于2017年获得浙江省卫计委、物价局批准通过(浙价医(201757号)。

(2)  中国非综合征性耳聋患者常见致聋基因突变谱和基因型分析:我们分析了1167个汉族非综合征性耳聋患者GJB2基因的编码区突变情况,总共检测到66个基因型(24个首次报道和41个已知),其中包括4个纯合突变,13复合杂合突变,20单杂合突变,28个基因多态性位点和野生型基因型。其中,116例(10.87%)为致病性突变纯合子,48个为(4.50%)复合杂合,62个(5.81%)为单杂合突变。统计结果提示21.18%的汉族非综合症耳聋是由于GJB2基因突变导致,该成果2015年发表在PLos One杂志(通讯作者)。此外,我们发现中国非综合征耳聋人群MARVELD2DFNB49)突变位点及频率不同于以往报到的巴基斯坦、斯洛伐克、匈牙利和罗马人群,该工作还首次筛选到新致聋候选突变MARVELD2 c.730G>A2018年发表在J Zhejiang Univ-Sci B (Biomed & Biotechnol) (通讯作者),三位审稿专家均给予了积极评价,认为该研究有助于进一步阐释MARVELD2 在非综合征耳聋中的作用。

(3)  携带线粒体12S rRNA 1555A>G突变人群耳聋易感性的差异分析 线粒体12S rRNA 1555A>G同质性突变是导致非综合征耳聋的重要原因,但临床上却呈现高度异质性,即使是来自同一家系的携带者也可表现出不同的耳聋易感性,说明其它因素参与耳聋发生,包括环境因子,线粒体单倍型和核修饰基因等。我们考察了142个携带12S rRNA 1555A> G突变的东亚地区耳聋患者三代以上家系和376个与上述家系没有遗传关系的听力正常对照,分析线粒体单体型对12S rRNA 1555 A>G突变携带者的耳聋易感性的影响。研究结果显示,线粒体单体型B与携带12S rRNA 1555A> G突变样本的听力损失易感性相关(包括氨基糖苷类药物暴露史,P =3D 0.0006;排除氨基糖甙类药物暴露史,P =3D 0.0031)。该工作首次提出了线粒体单体型B是亚洲携带12S rRNA 1555A> G突变人群出现听力损失的一个风险因素,论文2015年发表在Protein Cell (通讯作者)。同年,申请人在Protein Cell杂志撰写了修饰基因与耳聋易感性的综述文章,通过文献检索、生物信息学分析等方式,提出了TFB1MTRMUMTO1GTPBP3KARSYARS2VARS2TARS2LARS2等基因可能影响母系遗传性耳聋表型表达(通讯作者)。

(4)  构建线粒体疾病的斑马鱼模型研究线粒体与听觉异常的关系:斑马鱼近年来已成为研究脊椎动物发育与人类遗传疾病的新兴模式动物,我们的工作利用 MO (吗啡啉)技术敲低斑马鱼gtpbp3 基因,发现gtpbp3基因缺陷影响斑马鱼的发育和毛细胞功能,该表型可以通过注射野生型斑马鱼gtpbp3 mRNA获得改善,首次提出可以利用斑马鱼在整体水平开展线粒体tRNA与听觉异常,得到了同行其他研究组的肯定,工作发表在2016The International Journal of Biochemistry & Cell Biology上(通讯作者)。此后,申请人利用CRISPR/Cas9系统首次构建了trmumtu1)稳定敲除的斑马鱼模型,与管敏鑫教授团队合作从整体水平阐明了线粒体tRNA τm5s2U修饰酶trmu突变引起听力损失的分子机制,研究成果2018年底发表于知名学术期刊 Nucleic Acids Res(共同通讯作者);这些工作可以为遗传性聋的防治提供新的科学依据和潜在治疗靶点。

(5)  鉴定了1个新的遗传性耳聋致病基因:我们在三个非综合性征耳聋家系中筛查到了一个耳聋发病紧密相关的基因突变MAP1B c.4198A>Gp.1400S>G),经过在家系成员验证,发现所有患者均携带MAP1B c.4198A>G杂合突变,通过制备患者来源iPSCs、体外诱导听神经细胞分化、构建基因敲除动物模型等不同研究手段,发现MAP1B c.4198A>G突变打破了游离的动态微管蛋白与稳定态微管蛋白的平衡而影响微管组装,进一步影响类听神经细胞的成熟和延伸,最终导致听力下降;此外团队还利用CRISPR/Cas9技术实现了患者来源iPSCs MAP1b突变位点的矫正、进而修复听神经细胞电生理功能(PNAS修回,共同通讯作者)。

(6)  为特殊学校提供遗传咨询、积极参与耳聋防治社会工作:免费为聋哑学校学员提供常见耳聋基因检测、发放图形化可视简易基因信息卡片等。在临床样本筛查过程中,一旦发现氨基糖苷类药物性耳聋(m. 1555A>G, m. 1494C>T突变),为该先症者家系所有母系成员发放用药指南卡片,年来已经累积发放用药指南卡片2000余张;回访结果显示卡片发放人群药物性耳聋的风险得到有效控制,截至20195月该人群药物性耳聋发生率为0


三、岗位工作思路&= #21450;预期目标

1. 科研工作

 耳聋研究虽然是一个目前偏冷门的科研方向,但是其社会经济意义依然非常重要。尤其我国作为耳聋大国、高发国,但是目前有关耳聋的遗传学研究却依然匮乏,大量的基础科学问题亟待解决,耳聋的分子致病机制更是薄弱。申请人希望能够在岗位上带领团队坚持推动耳聋致病机制研究,力争推进耳聋的早期诊断和预警,助力健康中国战略的实施,任重而道远。

 预期目标:  通过基因筛查、细胞生理生化检测、动物模型等一系列技术手段进一步揭示遗传性耳聋发生的分子机制,为耳聋早期诊断、干预及治疗提供理论依据。研究工作的总体目标是最终降低出生缺陷发生率,符合我国社会经济发展重大战略需求。

 拟解决的科学问题: 基因变异引起的生物学功能障碍如何导致耳聋发生。

 主要工作方式: 申请人拟在现有基础上努力提升自己和团队的科研、教学水平,为推动耳聋基础研究、推进科学理论向临床应用转化做出贡献。利用5年左右的时间,(1)继续争取国家和省部级的基金支持、积极申报海外重点合作等项目,(2)培养研究生4-6人,其中博士研究生2-3人,建立一支结构合理的科研创新团队,(3)加快科研成果的临床转化应用,开发具有自主知识产权的基因诊断试剂、技术,(4)通过网络平台、科普宣传等途径带动更多的人和社会群体参与耳聋防治的工作。

 现有基础、团队:经过前面几年时间的积淀,申请人团队已经建立了稳定可靠的耳聋遗传资源收集和保存模式、积累超过2500例样本、建立了高效稳定的实验研究体系(原代细胞培养、患者源iPSC细胞构建、CRISPR/Cas9基因矫正、动物模型构建及表型检测等)、拥有一整套开展科学研究的常规仪器设备,可以保证项目的顺利开展。申请人所在的浙江大学遗传学研究所还提供了共享的科研辅助平台,研究所多位国家高层次特聘专家和青年教授领衔的团队分别在生物信息学分析、分子动力学模拟、遗传性疾病模型建立、线粒体能量代谢研究、干细胞分化、模型动物器官发育等不同方向开展工作,具备丰富的工作经验和成果积累能够,学术氛围浓郁、学术讨论活跃,为学术创新提供了源源不绝的活水之源。

 预期五年内可以取得的科研成果:(1)进一步绘制中国人群主要耳聋致病基因突变频谱,筛选出中国人群特有的热点突变;(2)发现 1-2 个新的遗传性耳聋致病基因,并阐明其生物学功能;(3)利用基因编辑建立致聋基因缺陷遗传校正模型,探索听力损伤修复的新途径;(4)取得一批具备国际水平和自主知识产权的原始创新成果,发表高质量论文4-6篇,并申请相关专利。


2. 教学

申请人2013年全职回国以来,主讲一门本科生课程和两门研究生课程。在此期间,申请人坚持跟随优秀教师现场听课学习、慕课学习等方式提高自身授课水平,课程教学受到了学生好评,2019年荣幸被评选为浙江大学竺可桢学院十名最佳任课教师之一,这是对我教学工作的一份莫大肯定也将一直鞭笞我前行。

在后续教学工作中,本人还将继续向优秀教师们虚心请教、认真学习,坚持育人为本、有效教学教学理念,时刻专注学科知识,把握住学科前沿,尽可能将学术科研与教学内容相结合,不断地更新补充教学内容;同时,更加关注学生知识点的掌握、教学的有效性,积极反思、总结自己的日常教学行为,不断提高自身教学水平。以《细胞工程》课程为例,教研组安排在本科三年级下半学年开课,这个阶段的生物学相关专业学生已经修完了《细胞生物学》、《分子生物学》、《生物化学》等基础学科,具备了足够的知识点,可以在课程中尽量与学生开展更多的互动,在这门交叉课程中通过讨论巩固旧的知识点、学习新的知识点。同时,《细胞工程》作为一个偏向应用的技术性课程,具有很强的前沿性,作为主讲教师需要主动搜集最新的相应领域的进展,运用多媒体的方式增强课堂的趣味性,把复杂内容简单化、抽象概念具体化,例如通过一些动画和图片使抽象的内容具体化、直观化、形象化,打造了轻松愉悦的学习环境,同时有利于重点突出难点的突破。当然更关键的是通过这样的教学讨论过程,增强学生的主动探究意识和自主学习的能力。  

3. 研究生培养

与本科生教育不同,研究生培养实行的导师制重点在于系统性的对学生进行科研训练,提升其创新能力,培养其独立完成科研任务的能力。近五年来,申请人指导的研究生已经有三位顺利获得硕士学位、一位获得博士学位,分别进入企事业单位就业承担教学、科研任务。本人的体会是研究生教育难点在于每个学生的性格与背景都不尽相同,无法用统一的模式来培养;所以在后续的工作中,我会坚持立德树人的职责,对每个学生精雕细琢,根据每个人的长处,选择不同的方案,在巡回迭代中,逐渐提高包括思想政治素质、学术创新能力、实践创新能力、以及社会责任感等。

4. 社会服务和其他

 作为大学教师,主要职能除了教学和科学研究以外,还有一个非常重要的工作就是社会服务。从样本到展品,最后成为废品,对于高校科研成果,这样的说法或许略显夸张,但也在某种程度上反映出高校科研与经济社会发展相脱节的困境;当前,我国正处在致力科技创新、加速追赶发展的关键期,高校作为创新体系中的重要一环,作为高校的一份子我们必须正确扮演好自己的角色。科研人员须积极响应国家号召,更多的走出去,到社会上寻找需求,然后解决这个需求,而非研究出结果再到社会上去推销。

后续工作中,申请人团队还将一如既往的联合合作医院坚持耳聋防治宣传、义诊的活动,提高人民群众爱耳、护耳意识,通过对前几年的工作回顾,我们欣喜的发现遗传咨询、用药指南发放等方法在减少听力残疾上已经发挥了重要作用;此外,我们还将积极推进科研成果的转化,例如耳聋基因筛查芯片推广、芯片的升级、感音神经性耳聋干细胞治疗的临床实验等,期望真实有效的推进我国的听力障碍预防与康复工作,为建设健康中国事业添砖加瓦。


&= #12289;任现职= 0197;来近5(根&#= 25454;所在院系任职基本Ĉ= 65;件要求的年限填写)主要业绩

4.1教学与人才= 521;养情况

1、共开设课= 243; 3 门,授课ਲ= 2;数共计 312 学时。其中= ;本科生课程 1 门,= 课程教学时数 120  学时,具体ঀ= 0;课情况如下:

教学= 年度,课程名称,授= 5838;对象,学生数,本ߟ= 4;学时数/课程总学时数,考核= 结果

1) 2018-2019 春, 细胞工程, 本科生, 78, 24/24,

2) 2017-2018 春, 细胞工程, 本科生, 96, 24/24,

3) 2016-2017 春, 细胞工程, 本科生, 75, 24/24,

4) 2015-2016 春, 细胞工程, 本科生, 78, 24/24, 优秀

5) 2014-2015 春, 细胞工程, 本科生, 81, 24/24,

1) 2018-2019 秋冬, 动物组织细胞培养技术, 研究生, 50, 32/32, 5.0/5

2) 2018-2019 春夏, 细胞工程, 研究生, 30, 32/32, 5.0/5

3) 2017-2018 秋冬, 动物组织细胞培养技术, 研究生, 34, 32/32, 5.0/5

4) 2016-2017 秋冬, 动物组织细胞培养技术, 研究生, 33, 32/32, 4.9/5

5) 2015-2016 秋冬, 动物组织细胞培养技术, 研究生, 35, 32/32, 4.9/5

6) 2014-2015 秋冬, 动物组织细胞培养技术, 研究生, 32, 32/32, 4.9/5

2、指导本科= 983;毕业论文(设计) 3 人(请列= 出姓名、专业、年级= 5289;

1) 张超凡, 求是科学班 (生物科学), 2012
2) 刘翰青, 临床医学八年制 巴德年班, 2012
3) 蒋乐健, 临床医学八年制 巴德年班, 2014

 

3、指导研究= 983; 9 (请列出研究生姓名、= 研究生类型、专业、= 4180;级)

1) 孟文芳, 硕士研究生, 细胞生物学, 2014
2) 高泽文, 硕士研究生, 细胞生物学, 2014
3) 李芡芡, 硕士研究生, 细胞生物学, 2015
4) 何秋芬, 博士研究生, 细胞生物学, 2015
5) 梅霜, 博士研究生, 遗传学, 2016
6) 何晓, 硕士研究生, 细胞生物学, 2017
7) 赵琼, 博士研究生, 遗传学, 2017
8) 胡晓佳, 博士研究生, 细胞生物学, 2018
9) 叶梦玲, 硕士研究生, 遗传学, 2018

 

4.2代表性论文 = 289;著作情况

1、共发表论= 991; 19 篇,其中作= 为第一作者或通讯作= 2773; 12 篇。

请按照您认为最具= 195;表性、重要性或影响= ;力的顺序列出

= 所有作者姓名(通讯= 0316;者名字前用“*”标示),论ă= 91;题目,发表期刊名称= ,出版年月,卷,期= 5292;起止页码,检索收ঈ= 5;情况,期刊影响因子&= #65292;他引次数,期刊级= 035;

1) Zhang Q, Zhang L, Chen D, He X, Yao S, Zhang Z, *Chen Y, *Guan MX, Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function, Nucleic Acids Research, 2018 Nov, 46, 20, 10930-10945, SCI, 11.147, ,

2) Ying Z, Zheng J, Cai Z, Liu L, Dai Y, Yao J, Wang H, Gao Y, Zheng B, Tang X, Zhu Y, Guan MX, *Chen Y, Mitochondrial haplogroup B increases the risk for hearing loss among the Eastern Asian pedigrees carrying 12S rRNA 1555A>G mutation, Protein & Cell, 2015 Nov, 6, 11, 844-8, SCI, 7.575, 4,

3) Chen C, *Chen Y, Guan MX, A peep into mitochondrial disorder: multifaceted from mitochondrial DNA mutations to nuclear gene modulation, Protein & Cell, 2015 Dec, 6, 12, 862-70, SCI, 7.575, 14,

4) Zheng J, Ying Z, Cai Z, Sun D, He Z, Gao Y, Zhang T, Zhu Y, *Chen Y, Guan MX, GJB2 Mutation Spectrum and Genotype-Phenotype Correlation in 1067 Han Chinese Subjects with Non-Syndromic Hearing Loss, PLoS One, 2015 Jun, 10, 6, e0128691-, SCI, 3.337, 13,

5) Hu X, Mei S, Meng W, Xue S, Jiang L, Yang Y, Hui L,*Chen Y , Guan MX, CXCR4-mediated signaling regulates autophagy and influences acute myeloid leukemia cell survival and drug resistance, Cancer Letter, 2018 Jul, 425, , 1-12, SCI, 6.508, 9,

6) Li Q, Gao Z, *Chen Y, Guan MX, The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells, Protein & Cell, 2017 Jun , 8, 6, 439-445, SCI, 7.575, 21,

7) Chen D, Li F, Yang Q, Tian M, Zhang Z, Zhang Q, *Chen Y, *Guan MX, The defective expression of gtpbp3 related to tRNA modification alters the mitochondrial function and development of zebrafish, The International Journal of Biochemistry & Cell Biology, 2016 May, 77, Pt A, 1-9, SCI, 3.654, ,

8) Hui L, *Chen Y, Tumor microenvironment: sanctuary of the devil, Cancer Letter, 2015 Nov , 368, 1, 7-13, SCI, 6.508, 77,

9) Zheng J, Meng WF, Zhang CF, Liu HQ, Yao J, Wang H, *Chen Y, Guan MX., New SNP variants of MARVELD2 (DFNB49) associated with non-syndromic hearing loss in Chinese population., J Zhejiang Univ Sci B, 2019 Feb, 20, 2, 164-169, SCI, 1.973, 1,

10) Zhang LW, Cang XH, *Chen Y, Guan MX., In vitro culture of mammalian inner ear hair cells., Journal of Zhejiang University SCIENCE B�, 2019 Feb, 20, 2, 170-179, SCI, 1.973, ,

11) Gao Z, *Chen Y, Guan MX, Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity, Journal of Otology, 2017 Mar , 12, 1, 1-8, , , ,

12) Meng W, Xue S, *Chen Y, The role of CXCL12 in tumor microenvironment, Gene, 2018 Jan , 641, , 105-110, SCI, 2.638, 17,

13) Chen X, Wang F, Maerhaba A, Li Q, Wang J, Liu X, Zheng J, Chen Y, *Guo Y, Novel mitochondrial gene variants in Northwestern Chinese probands with non-syndromic hearing loss by whole mitochondrial genome screening, Gene, 2018 Apr , 652, , 59-65, SCI, 2.638, ,

14) Tang X, Zheng J, Ying Z, Cai Z, Gao Y, He Z, Yu H, Yao J, Yang Y, Wang H, Chen Y, *Guan MX, Mitochondrial tRNASer(UCN) variants in 2651 Han Chinese subjects with hearing loss, Mitochondrion, 2015 May, 23, , 17-24, SCI, 3.226, 2,

15) Yu J, Zheng J, Zhao X, Liu J, Mao Z, Ling Y, Chen D, Chen C, Hui L, Cui L, Chen Y, Jiang P, *Guan MX, Aminoglycoside Stress Together with the 12S rRNA 1494C>T Mutation Leads to Mitophagy, PLoS One, 2014 Dec , 9, 12, e114650-, SCI, 2.776, 2,

16) Zhang W, Borthakur G, Gao C, Chen Y, Mu H, Ruvolo V, Nomoto K, Zhao N, Konopleva M, *Andreeff M, The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations., Cancer Research, 2016 Mar, 76, 6, 1528-1537, SCI, 8.378, 13,

17) Jiang P, Wang M, Xue L, Xiao Y, Yu J, Wang H, Yao J, Liu H, Peng Y, Liu H, Li H, Chen Y, *Guan MX, A hypertension-associated tRNAAla mutation alters the tRNA metabolism and mitochondrial function, Molecular and Cellular Biology, 2016 May , 36, 14, 1920-1930, SCI, 3.735, 7,

18) Jiang P, Jin X, Peng Y, Wang M, Liu H, Liu X, Ji Y, Liang M, Zhao F, Sun Y, Zhang M, Zhou X, Chen Y, Mo J, Huang T, Qu J, *Guan MX, The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leber’s hereditary optic neuropathy-associated mitochondrial DNA mutation, Human Molecular Genetics, 2016 Feb , 25, 3, 584-96, SCI, 4.544, 20,

19) Su X, Wang W, Ruan G, Liang M, Zheng J, Chen Y, Wu H, Fahey TJ, Guan M, *Teng L, A Comprehensive Characterization of Mitochondrial Genome in Papillary Thyroid Cancer, International Journal of Molecular Sciences, 2016 Oct, 17, 10, E1594-, SCI, 4.183, 7,

2、出版著作= 945;材共 本,总字数= ;为 万字,其ߑ= 3;为主编、副主编出版&= #20840;国统编教材 本,省部重= ;点、规划教材共 本:

= 所有作者姓名,书名= 5292;著作类型,出版地ᦁ= 2;出版社名称,出版年&= #26376;,个人字数/总字数,主编/副主编

 

4.3主要科研、= 945;改项目情况

1&#= 20849;参加项目 5 项,= 其中纵向项目 5 项,= 横向项目 0 <= /b>

主持= 项目到校总经费 193.96 万元,其中= 纵向项目到校经费 193.96 万元,横×= 21;项目到校经费 0 万元。

2、作为项目负责人৙= 5;担项目 4 项,= 其中纵向项目 4 项,= 横向项目 0 项。=

请按= 您认为最具代表性、= 7325;要性或影响力的顺ॴ= 7;列出:

= 项目名称,项目类别= 5292;项目性质,项目来଎= 4;,项目编号,本人主&= #25345;到校经费/项目总经费(万元),起始年月, = 456;止年月,项目成员

1) 子宫生育力保护与重塑的新技术及关键机制研究, 国家科技重大专项, 纵向, 科技部, 2018YFC1004803, 44.96/91.48/494, 2018-12, 2021-12,

2) 核修饰基因调控12S rRNA A1555G突变人群聋病表型表达的机制研究, 面上项目, 纵向, 国家基金委, 31671305, 69/72/72, 2017-01, 2020-12,

3) 单基因聋病新基因的鉴定, “973”计划, 纵向, 科技部, 2014CB541702, 50/50/202, 2016-01, 2018-12,

4) 听力损失防治新技术研究-干细胞治疗感音性听力损伤的技术体系建立, 浙江省医药卫生科技计划, 纵向, 浙江省科技厅, 2017C03G2010419, 0/50/165, 2018.01, 2021.12,

5) CXCR4介导的自噬信号通路在白血病细胞耐药发生中的作用机制研究, 浙江省自然科学基金, 纵向, 浙江省基金委, LR15H080001, 30/30/30, 2015-01, 2018-12,

 

4.4获得重要成= 524;奖励情况

共获= 成果奖 1 = &#= 65292;其中教材奖 0 <= span style=3D'font-family:SimSun'>项&#= 65292;教学成果奖 1 &#= 65292;科研成果奖 0 <= span style=3D'font-family:SimSun'>项。

请按= 您认为最具代表性、= 7325;要性或影响力的顺ॴ= 7;列出= :

= 所有获奖人员姓名,= 9033;目名称,奖励名称ᦁ= 2;获奖级别,授奖单位&= #65292;获奖年月,本人排= 517;/总人数

1) , , 2018年度浙江大学竺可桢学院最佳任课教师, , 浙江大学竺可桢学院, 2019.6,

4.5担任国际期刊Ņ= 34;委、国际学术会议重= 要职务及在国际学术= 0250;议全会报告、特邀ঢ়= 3;告情况

 入职浙江大学以来,本人积极参与国际学术活动,在亚洲线粒体生物医学及研究学会年会ASMRM 2014201520172018,全球华人遗传学大会GCCG 2016等国际学术会议中做分会场报告,报道我们团队在母系遗传性耳聋方向上取得的最新研究成果、和相关领域的专家进行探讨交流。 201910月我们团队将赴日本福冈参加ASMRM2019年会。其中,本人还作为主要工作人员筹备并全程参与组织了ASMRM 2015年会和GCCG 2016年会。

 过去5年中长期为 J CELL BIOCHEMCYTOTHERAPYGENEJOURNAL OF OTOLOGYSTEM CELLS DEVJ TRANSL MED等期刊担任审稿人。


 

4.6&= #33719;得专利情况

共获专利 1 项,其中发= ;明专利 1 项。

请按您认为= 368;具代表性、重要性或= ;影响力的顺序列出:

= 所有专利人员姓名,= 9987;利名称,专利类型ᦁ= 2;专利授权国,专利号&= #65292;授权公告年月,本= 154;排名/总人数

1) 管敏鑫,蒋萍萍,郑静,陈烨,冀延春, 一种先天性和易感性耳聋基因检测试剂盒, 发明专利, 中国, ZL201510575047.5, 2018年5月, 4/5

4.7其他获奖及荣Ţ= 65;情况=

2017:浙江大学医学院先进工作者

2016:浙江大学高峰学科建设支持计划遴选列入

2016:浙江大学医学院高层次人才培育支持专项计划列入

2015:浙江省自然科学基金杰出青年基金项目资助 2019年结题评价:优)

2013:浙江大学农生环学部优秀青年学者


4.8 社会服务及兼ň= 44;等情况=

中国细胞生物学学会    会员

浙江省遗传学会    常务理事

浙江省细胞生物学学会  会员


五、未列入业ń= 89;统计的其他能反映学= 术研究水平的突出业= 2489;

20137月入职浙江大学以来,其他未计入近五年业绩的纵向项目累计总经费189.5万元,具体主持情况包括:

1.  主持  国家自然科学基金面上项目:微环境对内耳毛细胞的保护作用及其分子机制研究  (81470685)2015.01-2018.12。主持经费73万元。

2.  课题骨干  国家重点基础研究发展计划  (973计划):关键聋病基因的动物模型建立及其生物学功能研究  (2014CB541703)2014.01-2015.12。到校经费16.5万元。

3.  主持  浙江大学高峰学科建设支持计划  培育经费,2016.01-2017.12。主持经费50万元。

4.  主持  浙江大学医学院高层次人才培育支持专项计划培育经费,2016.01-2016.12。主持经费30万元。

5.  主持  浙江大学自主科研计划项目(2014QNA6003)  2014.01-2015.12。主持经费20万元。

 

申请人在博士研究生和博士后培训期间主要利用动物模型研究成体干细胞和肿瘤微环境,相关工作发表在Journal of Clinical InvestigationBLOOD等国际主流学术期刊,工作受到了相关领域研究人员的广泛关注和引用。

在博士后期间(2009.9-2013.6),申请人获提名并入围Finalist of Bristol-Myers Squibb Award in Clinical Translational Research2011年)、获得MD Anderson Cancer Center Annual Research Awards 1st  place2012年)、获The Rolanette and Berdon Lawrence Research Award / Baylor College of Medicine基金会3万美元的经费支持用与人源化微环境小鼠模型的研究(2012年)。

申请人借助基因编辑技术在免疫缺陷小鼠上首次建立了人源骨髓微环境模型,实验结果证实了该微环境中的基质细胞、血管内皮细胞等均为人源性;并通过对间充质干细胞和内皮祖细胞的基因改造/修饰,实现了对该骨髓微环境的遗传控制,相应的工作分别在美国血液学年会和肿瘤学年会中被推选为优秀摘要,评价该模型的建立将为研究造血干/祖细胞、肿瘤细胞和人体骨髓微环境之间的相互作用和调控提供重要支持,研究成果发表在国际血液病学顶级期刊BLOOD上(BLOOD. 2012;119(21):4971-80.  第一作者,IF16.562,截止20199月,web of science  统计他引64);同时,申请人利用上述模型与MDACC的同事一起证明了HIF1aCTGFNFkb在骨髓微环境中表达对白血病细胞的归巢和增殖起到重要作用,为联合治疗提供了重要的微环境靶点(BLOOD. 2011;118(16):4431-9.  第三作者;BLOOD. 2013;122(3):357-66.  第二作者;Clin Cancer Res. 2014;20(9):2363-74第四作者;BLOOD. 2014 Apr 24;123(17):2691-702.第二作者)。

此外,申请人还构建了多种PDX小鼠模型,用于白血病治疗小分子化合物的筛选及作用机制研究,发现CXCR4抑制剂和抗肿瘤药物联合应用可以有效解决白血病细胞耐药性问题,该研究获得了同行的充分肯定,并已在MD Anderson Cancer Center实现部分临床应用转化(clinical trial),研究成果发表在国际顶级医学综合期刊Journal of Clinical Investigation  J Clin Invest. 2013;123(6):2395-407.  第一作者,IF12.784,截止20199月,web of science  统计他引110)和国际医学刊物Cancer LettersCancer Lett. 2018 Mar 21;425:1-12.  通讯作者,IF6.508,截止20199月,web of science  统计他引9)。

20152018年申请人应邀分别为Cancer LettersGene杂志撰写主题为靶向微环境(Targeting microenvironment的综述论文(Cancer Lett.  2015 Nov 1;368(1):7-13.  通讯作者,截止20199月,web of science  统计他引77次;Gene. 2018 Jan 30;641:105-110.  通讯作者,截止20199月,web of science  统计他引17次)。

 

 20137月申请人加入浙江大学工作,在973项目首席科学家管敏鑫教授引导下,将主要科研方向做出了调整,聚焦在听觉:耳聋的致病机制研究,希望能够利用遗传学研究所积累的临床病例资源优势、发挥工作特长、将前期热点研究领域的成功经验带入相对冷门的听觉研究;目前团队已取得一些重要进展并获得多项经费资助,希望我们的研究成果能为听觉研究领域增添新的浪花,为健康中国建设助力。


 

个人承诺

 

本人保证:所从事的学术研究符合学术道德规范要求;所提供的材料客观真实;符合申报要求和任职条件。

 

承诺人:<= b>3D"zf_image"       &nbs= p;          

2019年09月24日     

 

上述材料均已审核&#= 65292;内容真实,与证明Ĉ= 48;料原件相符。

 

审核人:3D"file_image"

 

2019年10月10日      

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日韩欧美福利视频_黑人巨大人精品欧美三区_欧美成人另类人妖_欧美在线精品一区二区三区_欧美一区二区三区性视频_日韩精品欧美视频_性欧美极品xxxx欧美一区二区





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日韩欧美福利视频_黑人巨大人精品欧美三区_欧美成人另类人妖_欧美在线精品一区二区三区_欧美一区二区三区性视频_日韩精品欧美视频_性欧美极品xxxx欧美一区二区
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