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1、共开设课 =
243; 4 门，授课ਲ=
2;数共计 185 学时。其中=
;本科生课程 4 门，=
课程教学时数 185 学时，具体ঀ=
0;课情况如下：
教学=
年度，课程名称，授=
5838;对象，学生数，本ߟ=
4;学时数/课程总学时数，考核=
结果
1)
2015春夏, Medical Microbiology and Parasitology, 本科生, 30, 18/30,
2)
2016秋冬, Medical Microbiology and Parasitology, 本科生, 30, 27/30,
3)
2017秋冬, Medical Microbiology and Parasitology, 本科生, 30, 9/30,
4)
2018春夏, 医学微生物学与免疫学, 本科生, 30, 9/52,
5)
2018春夏, 病原生物学（甲）, 本科生, 22, 18/78,
6)
2018春夏, 病原生物学与免疫学实验, 本科生, 82, 80/704,
7)
2019秋冬, Medical Microbiology and Parasitology, 本科生, 30, 24/30,
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1、共发表论=
991; 23 篇，其中作=
为第一作者或通讯作=
2773; 12 篇。
请按照您认为最具=
195;表性、重要性或影响=
;力的顺序列出：
=
所有作者姓名（通讯=
0316;者名字前用“*”标示），论ă=
91;题目，发表期刊名称=
，出版年月，卷，期=
5292;起止页码，检索收ঈ=
5;情况，期刊影响因子&=
#65292;他引次数，期刊级=
035;
1) Hu WL, Ge YM, Sun D, Dong HY, *Yang XF, *Yan J, p53-signaling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic Leptospira species, Cell Microbiol, 201310, 15, 10, 1624-1659, SCI, 5.04, 22, 权威期刊
2) Hu WL, Pappas CJ, Zhang JJ, Yang YY, Yan J, *Picardeau M, *Yang XF, The EbpA-RpoN regulatory pathway of the pathogen Leptospira interrogans is essential for survival in the environment, Appl Environ Microbiol, 201702, 83, 3, AEM.02377-16-, SCI, 4.70, 8, 权威期刊
3) Hu WL, Dong HY, Li Y, Ojciusd DM, *Li SJ, *Yan J, Bid-Induced release of AIF/EndoG from mitochondria causes apoptosis of macrophages during infection with Leptospira interrogans, Front Cell Infect Mi, 201711, 7, , 471-, SCI, 4.42, 2, 权威期刊
4) Hu WL, Xu’ai Lin, *Yan J, Leptospire and leptospirosis in China, Curr Opin Infect Dis, 201410, 27, 5, 432-436, SCI, 5.03, 9, 权威期刊
5) Li Y, Li KX, Hu WL(共一), Ojcius DM, Fang JQ, Li SJ, *Lin X, *Yan J, Endocytic recycling and vesicular transport systems mediate transcytosis of Leptospira interrogans across cell monolayer, Elife, 201904, 8, , e44594-, SCI, 8.52, 0, 权威期刊
6) Dong SL, Hu WL（共一）, Ge YM, Ojcius DM, Zhao JF, Lin XA, *Li LJ, *Yan J, A leptospiral AAA+ chaperone-Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis, Emerg Microbes Infec, 201711, 6, 11, e105-, SCI, 6.21, 3, 权威期刊
7) Fang JQ, Imran M, Hu WL(共一), Ojcius DM, Li Y, Ge YM, Li KX, *Lin X, *Yan J, vWA proteins of Leptospira interrogans induce hemorrhage in leptospirosis by competitive inhibition of vWF/GPIb-mediated platelet aggregation, EBioMedicine., 201810, 37, , 428-441, SCI, 6.68, 0, 权威期刊
8) Kassegne K, Hu WL(共一), Ojcius DM, Sun D, Ge YM, Yang XF, *Li LJ, *Yan J, Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic Leptospira species, J Infect Dis, 201409, 209, 7, 1105-1115, SCI, 6.02, 30, 权威期刊
9) Hua CZ, Hu WL(共一), Shang SQ, Li JP, *Hong LQ, *Yan J, Serum concentrations of antibodies against outer membrane protein P6, Protein D and their T- and B-cell combined antigenic epitopes of nontypeable Haemophilus influenzae in Children and adults of different ages, Clin Vaccine Immunol, 201512, 23, 2, 155-161, SCI, 3.23, 4, 权威期刊
10) 阮萍， 赵金方，李阳，严杰，*胡玮琳, 钩端螺旋体外膜蛋白 Loa22优势 T-B联合抗原表位及其免疫原性研究, 中华微生物学和免疫学杂志, 2015, 35, 4, 292-298, 中文核心期刊, , , 核心期刊
11) 张金良，李阳，楼宏强，严杰，*胡玮琳, 钩端螺旋体外膜蛋白GroEL优势T-B联合抗原表位及其免疫原性鉴定, 中华微生物学和免疫学杂志, 2015, 35, 9, 657-659, 中文核心期刊, , , 核心期刊
12) 方葆，李阳，严杰，*胡玮琳, CdaR-DAC信号系统调控钩端螺旋体合成第二信使分子c-di-AMP, 中华微生物学和免疫学杂志, 2018, 38, 12, 881-885, 中文核心期刊, , , 核心期刊
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1、&#=
20849;参加项目 10 项，=
其中纵向项目 10 项，=
横向项目 0 项<=
/b>；
主持=
项目到校总经费 54.6 万元，其中=
纵向项目到校经费 54.6 万元，横×=
21;项目到校经费 0 万元。
2、作为项目负责人=
5;担项目 6 项，=
其中纵向项目 6 项，=
横向项目 0 项。=
请按=
您认为最具代表性、=
7325;要性或影响力的顺ॴ=
7;列出：
=
项目名称，项目类别=
5292;项目性质，项目来=
4;，项目编号，本人主&=
#25345;到校经费/项目总经费(万元)，起始年月， =
456;止年月，项目成员
1) OmpR依赖TCS调控钩端螺旋体主要外膜蛋白抗原表达及LPS合成与变构 分子机制研究, 面上项目, 纵向, 国家自然科学基金委, 81971951, 0/55, 2020-01, 2024-12, 胡玮琳，夏肖萍，李立伟，罗绮霞，王赛赛，王继璇，宋丹丹，邵建伟，李淑佩
2) CdaR-DAC/PDE信号系统调控钩端螺旋体侵袭相关毒力因子表达的作用及机制, 青年科学基金项目, 纵向, 国家自然科学基金委, 81501713, 18/18, 2016-01, 2018-12, 胡玮琳,葛玉梅,吴一华,王继璇,方佳琪,李阳
3) EbpA/B-Sigma 54信号系统对钩端螺旋体代谢和毒力基因的表达调控作用, 一般纵向, 纵向, 浙江省自然科学基金委, LY18H190001, 5.6/5.6, 2018-01, 2021-12, 胡玮琳,王继璇,刘蒙,李阳,陈旭,方佳琪,张琴超
4) AcrAB-TolC/KtrA途径介导钩端螺旋体毒力因子分泌机制, 其他(中国博士后科学基金第9批特别资助), 纵向, 中国博士后科学基金, 2016T90547, 15/15, 2016-07, 2017-07, 胡玮琳
5) KdpDE-TCS调控钩端螺旋体毒力基因表达的作用及机制, 其他(中国博士后科学基金57批面上一等资助), 纵向, 中国博士后科学基金, 2015M570516, 8/8, 2015-07, 2017-07, 胡玮琳
6) 环二腺苷酸信号系统调控钩端螺旋体侵袭相关毒力因子表达的作用及机制, 其他(浙江大学自主科研计划（自然科学领域）), 纵向, 中央高校基本科研业务费专项资金, 2016QNA7016, 8/8, 2016-01, 2016-12, 胡玮琳，吴一华，王继璇，李阳，葛玉梅，方佳琪，胡小伟
7) ERS/VTS介导问号钩端螺旋体跨细胞转运及肾细胞内繁殖与出胞的分子机制, 面上项目, 纵向, 国家自然科学基金委, KN20161724, /60, 2017-01, 2020-12, 严杰,胡玮琳,刘蒙,李阳,王继璇,方佳琪,邵建伟,陈旭,李凯旋
8) 钩端螺旋体vwa基因产物竞争性抑制vWF介导血小板聚集引发出血分子机制, 面上项目, 纵向, 国家自然科学基金委, 81471907, /75, 2015-01, 2018-12, 严杰，胡玮琳，李立伟，田莉，孙爱华，方佳琪，葛玉梅，董世雷
9) 淋病奈瑟菌治疗性疫苗免疫效应评价及临床前研究, 其他(浙江省省部共建项目), 纵向, 浙江省卫计委, WKJ-ZJ-1511, /15, 2015-01, 2017-12, Stijn van der Veen,林旭瑷,李立伟,倪春山,刘晶洁,薛娟,胡玮琳
10) 钩端螺旋体溶血素调控NLRP3炎症小体活化介导炎症反应机制, 浙江省自然科学基金, 纵向, 浙江省自然科学基金委, Y17H190013, /8, 2017.01, 2019.12, 林旭瑷，胡玮琳，肖国辉，车荣波，孔亮亮，义玉思，张琴超
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担任“美国微生物学会（American Society for Microbiology, ASM）”会员，“国际钩端螺旋体学会 (International Leptospirosis Society, ILS)”会员。参加国际会议12次，其中国际学术会议全会报告7次，墙报展示5次。2013年在日本举办第8届国际钩端螺旋体病学学术会议上展示通用型钩端螺旋体抗原表位肽基因工程疫苗的阶段性研究工作，获得美国国立卫生研究院（NIH）颁发的 “Travel Award”奖励（全球十人中唯一华人）。2018-2019年获国家留学基金委资助作为访问学者赴耶鲁大学交流。2019年在加拿大举办第11届国际钩端螺旋体病学学术会议上展示钩端螺旋体第二信使调控通路的阶段性研究工作获得国际钩端螺旋体学会（ILS）颁发的“青年学者奖”。目前已获国际著名戈登会议(Gordon Research Conference)邀请将于2020年赴意大利做大会报告(本领域首位获邀中国学者)。 国际会议： 1. 2012/10/25-28. (Beijing,China).13th Asia-Pacific Congress of Clinical Microbiology and Infection (APCCMI). Yan J, Hu WL. “p53-signaling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic Leptospira species”. Poster presentation. 2. 2013/4/12-13. (Indianapolis, U.S). Indiana Branch of the American Society of Microbiology (IBASM). Hu WL, Zhang JJ, Yang YY, Yang XF. “RpoN regulatory network in Leptospira interrogans”. Poster presentation. 3. 2013/10/8-11. (Fukuoka,Japan). 8th Scientific Meeting of International Leptospirosis Society (ILS). Hu WL, Sun AH, Ojcius DM, Sun D, Ge YM, Fang JQ, Li Y, Lin XA, Yan J. “Identification of predominant T- and B-cell epitopes in genus-specific outer membrane proteins of Leptospira interrogans”. Poster presentation. 4. 2013/10/8-11. (Fukuoka,Japan). 8th Scientific Meeting of International Leptospirosis Society (ILS). Zhang CL*, Hu WL*, Sun AH, Yang XF, Ge YM, Fang JQ, Li Y, Ruan P, Ojcius DM, Li LJ, Yan J. “Elevation of lipopolysaccharide synthesis and structural change of lipid A for increasing virulence of Leptospira interrogans during infection of macrophages”. Oral presentation. 5. 2013/10/8-11. (Fukuoka,Japan). 8th Scientific Meeting of International Leptospirosis Society (ILS). Yang XF, Zhang JJ, Hu WL, Yan J, Picardeau M. “The RpoN regulatory network in Leptospira”. Oral presentation. 6. 2014/10/16-17. (Berlin, Germany) German Symposium on Zoonoses Research 2014 and 7th International Conference on Emerging Zoonoses. Pappas CJ, Hu WL (co-first author), Zhang JJ, Yang YY, Yan J, Picardeau M, Yang XF. Formate hydrogenlyase activator (FhlA) enhances Rpon regulated gene expression in Leptospira interrogans. Poster presentation. 7. 2015/10/7-10. (Semarang, Indonesia). 9th Scientific Meeting of International Leptospirosis Society (ILS). Hu WL, Pappas CJ., Zhang JJ, Yang YY, Yan J, Picardeau M, Yang XF. FhlA, a transcriptional activator of sigma factor RpoN, regulates nitrogen metabolism, cell morphology and virulence in L. interrogans. Oral presentation. 8. 2015/10/7-10. (Semarang, Indonesia). 9th Scientific Meeting of International Leptospirosis Society (ILS). Dong SL, Hu WL (co-first author), Ge YM, Ojcius DM, Sun AH, Yan J. HslUV proteasome contributes to the survival of Leptospira interrogans in hosts and the transmission of leptospirosis. Oral presentation. 9. 2015/11/1. (Taibei/Taiwan). Zhang CL, Hu WL (co-first author), Sun AH, Yang XF, Ge YM, Ojcius DM, Li LJ, Yan J. Elevation of lipopolysaccharide synthesis and structural change of lipid A for increasing virulence of Leptospira interrogans during infection of macrophages. 10. 2016/1/10-15 (Ventura, California/U.S). The Gordon Research Conference on the Biology of Spirochetes. Pappas CJ., Hu WL (co-first author), Zhang JJ, Yang YY, Yan J, Picardeau M, Yang XF. An enhancer binding protein (EbpA) affects RpoN dependent gene expression in Leptospira interrogans. 11. 2017/11/27-12/1. (Palmerston North, New Zealand). 10th Scientific Meeting of International Leptospirosis Society (ILS). Hu WL, Yan J. Identification of novel c-di-AMP signaling-associated proteins of Leptospira interrogans. Poster presentation. 12. 2019/07/08-07/12. (Vancouver, Canada). 11th Scientific Meeting of International Leptospirosis Society (ILS). Hu WL, Wunder Jr EA, Bai GC, Picardeau M, Ko A, Yan J. Identification and Characterization of the Cyclic di-AMP binding Potassium Uptake System Ktr in Leptospira interrogans. Oral presentation.
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