Human health has been challenged by multidrug resistant microorganisms for several decades. Herein, we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of pathogenic strains, including drug-resistant Klebsiella pneumoniae, Vancomycin-resistant enterococcus, Methicillin-resistant Staphylococcus aureus and fluconazole-resistant yeast Cryptococcus neoformans, while displaying minimal hemolysis (HC(50)/MIC values over 3000) and a very high therapeutic index of 37 for killing S. aureus under inflammatory conditions in vivo. The paper was published in Biomaterials
Over recent decades, A. baumannii has emerged as a major global hospital-acquired pathogen. Bloodstream infections (BSIs) caused by this bacterium carry a mortality rate of up to 60% and imp...
SAHZU Neurologist Prof. LOU Min and her team recently found that, despite an increased risk of symptomatic intracranial hemorrhage, intravenous alteplase provided functional benefit to acute ischemic ...
The genome, made up of DNA, contains not only protein-coding sequences but also a vast array of non-coding regulatory sequences. These two types of sequence work in concert to shape the complex phenot...
