The expression of histamine receptor 1-4 (H1- 4R) and histamine methyltransferase was determined in the histamine projection areas which are strongly involved in Parkinson’s disease (PD), i.e. the substantia nigra and striatum, with quantitative polymerase chain reaction and immunocytochemistry. In addition, the relationship between the expression of these molecules and PD pathologies and disease course were analyzed. We found for the first time brain-area-specific changes of neuronal histaminergic system in PD. This may provide scientific evidence for novel therapeutic strategies. The paper was published in Neurobiology of Aging.
Over recent decades, A. baumannii has emerged as a major global hospital-acquired pathogen. Bloodstream infections (BSIs) caused by this bacterium carry a mortality rate of up to 60% and imp...
SAHZU Neurologist Prof. LOU Min and her team recently found that, despite an increased risk of symptomatic intracranial hemorrhage, intravenous alteplase provided functional benefit to acute ischemic ...
The genome, made up of DNA, contains not only protein-coding sequences but also a vast array of non-coding regulatory sequences. These two types of sequence work in concert to shape the complex phenot...
