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Dr. Tianhua Zhou's Group Discovers a Novel Function of NudC in Regulating Actin Dynamics, Cilio

2016-01-13   |  

Cilia are evolutionarily conserved microtubule-based organelles projecting from the surface of most vertebrate cell types, which play crucial roles in embryonic development and tissue homeostasis. Defects in ciliary assembly or function lead to a wide range of human diseases termed ciliopathies, including polycystic kidney disease, situs inversus and hydrocephalus. Recent studies show that actin dynamics is associated with ciliogenesis. However, the underlying mechanism remains unclear.